6 I.P. Pavlova St., 77520, Olomouc, CZ
phone:  +420 58 5632771, fax: +420 58 5415116

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1st July 2014. The Laboratory now constitutes a research component of the Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University Olomouc. It keeps close collaboration within several units at the University Hospital Olomouc, primarily Molecular Pathology, Cardiology, Respiratory and Transplantation Medicine. The Laboratory further collaborated with various research centres of the Palacky University including the Institute of Molecular and Translational Medicine, in the premises of which it is also located. The laboratory research direction has not changed in principle and several new aspects of immune gene regulation and inflammatory disease pathogenesis have been addressed.

The mission of Laboratory of Immunogenomics and Immunoproteomics is to explore genes involved in transplantation situations and in pathogenesis of complex disease with immune component. We aim at identification of susceptibility/protection genes and also search for genes modifying disease remission/progression. In order to get full insight into the underlying mechanisms, expression of revealed genes is explored at mRNA and proteomic level by means of most up-to-date technologies such as real time PCR and SELDI-TOF mass spectrometry.  The laboratory,  linked both to the Dept. of Immunology, Palacky University Faculty of Medicine and to the Tissue Typing Laboratory, Faculty Hospital Olomouc, participates in a number of collaborations on international and local level and is funded by grants from Czech and international funding bodies, and partially also by the Rector of the Palacky University.

We would be happy if our pieces of work on particular genes, proteins and their complexes may contribute to  understanding of immune system in health and disease within the „Systems Biology“ (SB) approach SB aims to view an organism as an integrated and interacting network of genes, proteins and biochemical reactions which give rise to life. In this interpretation, “the immune system is not the result of a single mechanism or gene. Rather the interactions of numerous genes, proteins, mechanisms and the organism´s external environment, produce immune responses to fight infections and diseases”.  
For more about Systems Biology: the 21 st Century Science see: http://www.systemsbiology.org, from where part of the above text was adopted.